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Article

Adverse impact of IDH1 and IDH2 mutations in primary AML: experience of the Spanish CETLAM group.

Leukemia research - 1 Aug 2012

Nomdedéu J, Hoyos M, Carricondo M, Esteve J, Bussaglia E, Estivill C, Ribera J M, Duarte R, Salamero O, Gallardo D, Pedro C, Aventin A, Brunet S, Sierra J

Abstract excerpt

The study of genetic lesions in AML cells is helpful to define the prognosis of patients with this disease. This study analyzed the frequency and clinical impact of recently described gene alterations, isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) mutations, in a series of homogeneously treated patients with primary (de novo) AML. Two-hundred and seventy-five patients enrolled in the...

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Source

Identifiers

PMID: 22520341
DOI: 10.1016/j.leukres.2012.03.019

Genes

IDH2
IDH1
FLT3
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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