Article
Reconstitution of high-level micafungin resistance detected in a clinical isolate of Candida glabrata identifies functional homozygosity in glucan synthase gene expression.
The Journal of antimicrobial chemotherapy - 1 Jul 2012
Niimi Kyoko, Woods Matthew A, Maki Katsuyuki, Nakayama Hironobu, Hatakenaka Kazuaki, Chibana Hiroji, Ikeda Fumiaki, Ueno Keigo, Niimi Masakazu, Cannon Richard D, Monk Brian C
Abstract excerpt
OBJECTIVES: A mechanism for the acquisition of high-level echinocandin resistance in Candida glabrata was investigated. FKS mutants were constructed to: determine whether clinically significant micafungin resistance requires a hot-spot mutation in FKS1 and a premature stop codon in FKS2, as was observed in a clinical isolate; select for variants with reduced susceptibility and locate mutations in FKS genes; and...
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