Article
[GATA1-mutation associated leukemia in children with trisomy 21 mosaic].
Klinische Padiatrie - 1 Apr 2012
Reinhardt D, Reinhardt K, Neuhoff C, Sander A, Klusmann J-H, Pekrun A, Sauerbrey A, von Stackelberg A, Rössig C, Creutzig U, Kolenova A
Abstract excerpt
Mutations of the hematopoietic transcription factor GATA1 (GATA1s) are pathognomonic in newborn with transient leukemia and children with Down syndrome and myeloid leukemia (ML-DS). Both TL and ML-DS can also occur in children with trisomy 21 mosaic.Between 2002 and 2011, 15 newborns and infants were diagnosed with DS mosaic. 9 of them presented with TL and 8 children suffered from ML-DS; 2 of them with a history...
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