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Article

A rare case of GATA1 negative chemoresistant acute megakaryocytic leukemia in an 8-month-old infant with trisomy 21.

Pediatric blood & cancer - 1 Jul 2010

Stepensky Polina, Brooks Rebecca, Waldman Elisha, Revel-Vilk Shoshana, Izraeli Shai, Resnick Igor, Weintraub Michael

Abstract excerpt

Children with Down syndrome (DS) have a unique form of acute megakaryocytic leukemia (AMKL) characterized by the presence of mutations in the GATA1 gene leading to increased chemosensitivity and a favorable outcome. We describe an 8-month-old male with DS who was diagnosed with AMKL without a mut...

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Source

Identifiers

PMID: 20108342
DOI: 10.1002/pbc.22331

Genes

GATA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20108342-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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