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Article

Defining a gene promoter methylation signature in sputum for lung cancer risk assessment.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jun 2012

Leng Shuguang, Do Kieu, Yingling Christin M, Picchi Maria A, Wolf Holly J, Kennedy Timothy C, Feser William J, Baron Anna E, Franklin Wilbur A, Brock Malcolm V, Herman James G, Baylin Stephen B, Byers Tim, Stidley Christine A, Belinsky Steven A

Abstract excerpt

PURPOSE: To evaluate the methylation state of 31 genes in sputum as biomarkers in an expanded nested, case-control study from the Colorado cohort, and to assess the replication of results from the most promising genes in an independent case-control study of asymptomatic patients with stage I lung cancer from New Mexico. EXPERIMENTAL DESIGN: Cases and controls from Colorado and New Mexico were interrogated for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22510351
DOI: 10.1158/1078-0432.CCR-11-3049
PMCID: PMC3483793

Genes

GATA5
SULF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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