Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Directional selection and the site-frequency spectrum.

Genetics - 1 Dec 2001

Bustamante C D, Wakeley J, Sawyer S, Hartl D L

Abstract excerpt

In this article we explore statistical properties of the maximum-likelihood estimates (MLEs) of the selection and mutation parameters in a Poisson random field population genetics model of directional selection at DNA sites. We derive the asymptotic variances and covariance of the MLEs and explore the power of the likelihood ratio tests (LRT) of neutrality for varying levels of mutation and selection as well as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Likelihood Functions
Share to Models, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Statistical

Share to Poisson Distribution

Share to Recombination, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 11779814
DOI: 10.1093/genetics/159.4.1779
PMCID: PMC1461920

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Directional selection and the site-frequency spectrum.PMID 11779814Read ↗

The Site Frequency Spectrum under Finite and Time-Varying Mutation RatesSemantic proximity Read ↗

Estimating the scaled mutation rate and mutation bias with site frequency data.Semantic proximity Read ↗

Inference of site frequency spectra from high-throughput sequence data: quantification of selection on nonsynonymous and synonymous sites in humans.Semantic proximity Read ↗

Inference of directional selection and mutation parameters assuming equilibrium.Semantic proximity Read ↗

Multivariate phase-type theory for the site frequency spectrum.Semantic proximity Read ↗

Maximum likelihood and Bayesian methods for estimating the distribution of selective effects among classes of mutations using DNA polymorphism data.Semantic proximity Read ↗

Extensively Parameterized Mutation-Selection Models Reliably Capture Site-Specific Selective Constraint.Semantic proximity Read ↗

Population genetics of polymorphism and divergence for diploid selection models with arbitrary dominance.Semantic proximity Read ↗

Maximum likelihood estimators for scaled mutation rates in an equilibrium mutation-drift model.Semantic proximity Read ↗

Statistical Inference in the Wright-Fisher Model Using Allele Frequency Data.Semantic proximity Read ↗

General triallelic frequency spectrum under demographic models with variable population size.Semantic proximity Read ↗

Site frequency spectra from genomic SNP surveys.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.