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Identification of MYCN Gene Amplification in Neuroblastoma Using Chromogenic In Situ Hybridization (CISH)

19 May 2005

Abstract excerpt

Chromogenic in situ hybridization (CISH) is a recently developed technique, which utilizes the general principles of in situ hybridization and a detection system similar to immunohistochemistry. To assess the utility of CISH for analysis of MYCN gene amplification, we compared this assay with established diagnostic assays such as Southern blot analysis (SB) and fluorescent in situ hybridization (FISH). CISH was...

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PMID: 15905689
DOI: 10.1097/01.pas.0000149878.78117.ff

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