Induction of Circles of Heterogeneous Sizes in Carcinogen-Treated Cells: Two-Dimensional Gel Analysis of Circular DNA Molecules

Abstract excerpt

Extrachromosomal circular DNA molecules are associated with genomic instability, and circles containing inverted repeats were suggested to be the early amplification products. Here we present for the first time the use of neutral-neutral two-dimensional (2D) gel electrophoresis as a technique for the identification, isolation, and characterization of heterogeneous populations of circular molecules. Using this...

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