Article
Method for physiologic phenotype characterization at the single-cell level in non-interacting and interacting cells.
Journal of biomedical optics - 1 Mar 2012
Kelbauskas Laimonas, Ashili Shashanka P, Houkal Jeff, Smith Dean, Mohammadreza Aida, Lee Kristen B, Forrester Jessica, Kumar Ashok, Anis Yasser H, Paulson Thomas G, Youngbull Cody A, Tian Yanqing, Holl Mark R, Johnson Roger H, Meldrum Deirdre R
Abstract excerpt
Intercellular heterogeneity is a key factor in a variety of core cellular processes including proliferation, stimulus response, carcinogenesis, and drug resistance. However, cell-to-cell variability studies at the single-cell level have been hampered by the lack of enabling experimental techniques. We present a measurement platform that features the capability to quantify oxygen consumption rates of individual,...
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