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Article

PU.1 is linking the glycolytic enzyme HK3 in neutrophil differentiation and survival of APL cells

13 Apr 2012

Abstract excerpt

The transcription factor PU.1 is a master regulator of myeloid differentiation and function. On the other hand, only scarce information is available on PU.1-regulated genes involved in cell survival. We now identified the glycolytic enzyme hexokinase 3 (HK3), a gene with cytoprotective functions, as transcriptional target of PU.1. Interestingly, HK3 expression is highly associated with the myeloid lineage and was...

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PMID: 22498738
DOI: 10.1182/blood-2011-09-378117

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