Article
Regulation of the hematopoietic cell kinase (HCK) by PML/RARα and PU.1 in acute promyelocytic leukemia.
Leukemia research - 1 Feb 2012
Zou Dandan, Yang Xianwen, Tan Yun, Wang Ping, Zhu Xuehua, Yang Wentao, Jia Xiaohong, Zhang Ji, Wang Kankan
Abstract excerpt
This study investigates the dynamic regulation of human hematopoietic cell kinase (HCK) in acute promyelocytic leukemia (APL) and the underlying molecular mechanisms. First, the level of HCK in APL blasts was found lower than that in normal granulocytes and monocytes. Second, the HCK promoter was repressed by PML/RARα and this repression required PU.1. PU.1 was capable of transactivating the HCK promoter through...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.