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Article

Rapid screening for the mitochondrial DNA C1494T mutation in a deaf population in China using real-time quantitative PCR.

Acta oto-laryngologica - 1 Aug 2012

Li Qi, Yuan Yong-Yi, Huang De-Liang, Han Dong-Yi, Dai Pu

Abstract excerpt

CONCLUSION: Real-time quantitative polymerase chain reaction (qPCR) with a TaqMan minor groove binding (MGB) probe is useful for large-scale screening for the C1494T mutation. The mitochondrial DNA(mtDNA) C1494T mutation has a low carrier frequency in Chinese patients with nonsyndromic hearing loss. OBJECTIVE: To develop a simple, rapid, and reliable real-time qPCR assay based on TaqMan technology using a new MGB...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22497215
DOI: 10.3109/00016489.2012.664781

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