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Article

Rapid and Reliable Detection of Nonsyndromic Hearing Loss Mutations by Multicolor Melting Curve Analysis.

Scientific reports - 22 Feb 2017

Wang Xudong, Hong Yongjun, Cai Peihong, Tang Ning, Chen Ying, Yan Tizhen, Liu Yinghua, Huang Qiuying, Li Qingge

Abstract excerpt

Hearing loss is a common birth defect worldwide. The GJB2, SLC26A4, MT-RNR1 and MT-TS1 genes have been reported as major pathogenic genes in nonsyndromic hearing loss. Early genetic screening is recommended to minimize the incidence of hearing loss. We hereby described a multicolor melting curve analysis (MMCA)-based assay for simultaneous detection of 12 prevalent nonsyndromic hearing loss-related mutations. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28225033
DOI: 10.1038/srep42894
PMCID: PMC5320477

Genes

GJB2

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