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Article

MGB probe assay for rapid detection of mtDNA11778 mutation in the Chinese LHON patients by real-time PCR.

Journal of Zhejiang University. Science. B - 1 Aug 2008

Wang Jian-yong, Gu Yang-shun, Wang Jing, Tong Yi, Wang Ying, Shao Jun-bing, Qi Ming

Abstract excerpt

OBJECTIVE: Leber's hereditary optic neuropathy (LHON) is a maternally inherited degeneration of the optic nerve caused by point mutations of mitochondrial DNA (mtDNA). Many unsolved questions regarding the penetrance and pathophysiological mechanism of LHON demand efficient and reliable mutation testing. This study aims to develop a minor groove binder (MGB) probe assay for rapid detection of mtDNA11778 mutation...

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Source

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Identifiers

PMID: 18763310
DOI: 10.1631/jzus.B0820058
PMCID: PMC2491690

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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