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Phylogeny to function: PE / PPE protein evolution and impact on M ycobacterium tuberculosis pathogenicity

26 Feb 2015

Abstract excerpt

The pe/ppe genes represent one of the most intriguing aspects of the Mycobacterium tuberculosis genome. These genes are especially abundant in pathogenic mycobacteria, with more than 160 members in M. tuberculosis. Despite being discovered over 15 years ago, their function remains unclear, although various lines of evidence implicate selected family members in mycobacterial virulence. In this review, we use...

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PMID: 25727695
DOI: 10.1111/mmi.12981

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