Article
Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data.
PLoS genetics - 1 Sept 2017
Camacho Niedzica, Van Loo Peter, Edwards Sandra, Kay Jonathan D, Matthews Lucy, Haase Kerstin, Clark Jeremy, Dennis Nening, Thomas Sarah, Kremeyer Barbara, Zamora Jorge, Butler Adam P, Gundem Gunes, Merson Sue, Luxton Hayley, Hawkins Steve, Ghori Mohammed, Marsden Luke, Lambert Adam, Karaszi Katalin, Pelvender Gill, Massie Charlie E, Kote-Jarai Zsofia, Raine Keiran, Jones David, Howat William J, Hazell Steven, Livni Naomi, Fisher Cyril, Ogden Christopher, Kumar Pardeep, Thompson Alan, Nicol David, Mayer Erik, Dudderidge Tim, Yu Yongwei, Zhang Hongwei, Shah Nimish C, Gnanapragasam Vincent J, Isaacs William, Visakorpi Tapio, Hamdy Freddie, Berney Dan, Verrill Clare, Warren Anne Y, Wedge David C, Lynch Andrew G, Foster Christopher S, Lu Yong Jie, Bova G Steven, Whitaker Hayley C, McDermott Ultan, Neal David E, Eeles Rosalind, Cooper Colin S, Brewer Daniel S
Abstract excerpt
A variety of models have been proposed to explain regions of recurrent somatic copy number alteration (SCNA) in human cancer. Our study employs Whole Genome DNA Sequence (WGS) data from tumor samples (n = 103) to comprehensively assess the role of the Knudson two hit genetic model in SCNA generation in prostate cancer. 64 recurrent regions of loss and gain were detected, of which 28 were novel, including regions...
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