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Loss of lamin B1 is a biomarker to quantify cellular senescence in photoaged skin

9 Nov 2017

Abstract excerpt

Skin ageing is an inevitable consequence of life and accelerated by exposure to ultraviolet (UV) rays. Senescence is an irreversible growth arrest and senescent cells accumulate in ageing tissues, at sites of age-related pathologies and in pre-neoplastic lesions. Conventionally, senescent cells have been detected by senescence associated-β-galactosidase (SA-β-gal) staining, a procedure that requires enzymatic...

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PMID: 29142250
DOI: 10.1038/s41598-017-15901-9

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