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Knockdown of Autophagy Inhibits Infectious Hepatitis C Virus Release by the Exosomal Pathway

19 Nov 2015

Abstract excerpt

UNLABELLED: Hepatitis C virus (HCV) is a major cause of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma in humans. We showed previously that HCV induces autophagy for viral persistence by preventing the innate immune response. Knockdown of autophagy reduces extracellular HCV release, although the precise mechanism remains unknown. In this study, we observed that knockdown of autophagy genes...

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PMID: 26581990
DOI: 10.1128/jvi.02383-15

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