Article
Predisposition to Childhood Otitis Media and Genetic Polymorphisms within the Toll-Like Receptor 4 (TLR4) Locus.
PloS one - 1 Jan 2015
Hafrén Lena, Einarsdottir Elisabet, Kentala Erna, Hammarén-Malmi Sari, Bhutta Mahmood F, MacArthur Carol J, Wilmot Beth, Casselbrant Margaretha, Conley Yvette P, Weeks Daniel E, Mandel Ellen M, Vaarala Outi, Kallio Anna, Melin Merit, Nieminen Janne K, Leinonen Eira, Kere Juha, Mattila Petri S
Abstract excerpt
BACKGROUND: Predisposition to childhood otitis media (OM) has a strong genetic component, with polymorphisms in innate immunity genes suspected to contribute to risk. Studies on several genes have been conducted, but most associations have failed to replicate in independent cohorts. METHODS: We investigated 53 gene polymorphisms in a Finnish cohort of 624 cases and 778 controls. A positive association signal was...
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