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Article

Genetic polymorphisms in immunoresponse genes TNFA, IL6, IL10, and TLR4 are associated with recurrent acute otitis media.

Pediatrics - 1 Oct 2007

Emonts Marieke, Veenhoven Reinier H, Wiertsema Selma P, Houwing-Duistermaat Jeanine J, Walraven Vanessa, de Groot Ronald, Hermans Peter W M, Sanders Elisabeth A M

Abstract excerpt

OBJECTIVE: Cytokines and other inflammatory mediators are involved in the pathogenesis of otitis media. We hypothesized that polymorphisms in inflammatory response genes contribute to the increased susceptibility to acute otitis media in otitis-prone children. PATIENTS AND METHODS: DNA samples from 348 children with > or = 2 acute otitis media episodes, who were participating in a randomized, controlled...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17908769
DOI: 10.1542/peds.2007-0524

Genes

TLR4
TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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