Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expansion of somatically reverted memory CD8+ T cells in patients with X-linked lymphoproliferative disease caused by selective pressure from Epstein-Barr virus.

The Journal of experimental medicine - 7 May 2012

Palendira Umaimainthan, Low Carol, Bell Andrew I, Ma Cindy S, Abbott Rachel J M, Phan Tri Giang, Riminton D Sean, Choo Sharon, Smart Joanne M, Lougaris Vassilios, Giliani Silvia, Buckley Rebecca H, Grimbacher Bodo, Alvaro Frank, Klion Amy D, Nichols Kim E, Adelstein Stephen, Rickinson Alan B, Tangye Stuart G

Abstract excerpt

Patients with the primary immunodeficiency X-linked lymphoproliferative disease (XLP), which is caused by mutations in SH2D1A, are highly susceptible to Epstein-Barr virus (EBV) infection. Nonetheless, some XLP patients demonstrate less severe clinical manifestations after primary infection. SH2D...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD8-Positive T-Lymphocytes
Share to Flow Cytometry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Herpesvirus 4, Human

Share to Immunologic Memory

Share to Intracellular Signaling Peptides and Proteins

Share to Lymphoproliferative Disorders

Share to Signaling Lymphocytic Activation Molecule Associated Protein

Share to Viral Load

Source

Open in PubMed Open full text

Identifiers

PMID: 22493517
DOI: 10.1084/jem.20112391
PMCID: PMC3348103

Genes

CCR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22493517-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expansion of somatically reverted memory CD8+ T cells in patients with X-linked lymphoproliferative disease caused by selective pressure from Epstein-Barr virus.PMID 22493517Read ↗

Impaired Epstein-Barr virus–specific CD8+ T-cell function in X-linked lymphoproliferative disease is restricted to SLAM family–positive B-cell targetsSemantic proximity Read ↗

XLP: clinical features and molecular etiology due to mutations in SH2D1A encoding SAP.Semantic proximity Read ↗

X-linked lymphoproliferative disease (XLP): a model of impaired anti-viral, anti-tumor and humoral immune responses.Semantic proximity Read ↗

X-linked lymphoproliferative disease type 1: a clinical and genetic updateSemantic proximity Read ↗

Molecular pathogenesis of EBV susceptibility in XLP as revealed by analysis of female carriers with heterozygous expression of SAP.Semantic proximity Read ↗

X-linked lymphoproliferative syndromes and related autosomal recessive disorders.Semantic proximity Read ↗

SAP mediates specific cytotoxic T-cell functions in X-linked lymphoproliferative diseaseSemantic proximity Read ↗

X-linked lymphoproliferative disease: a progressive immunodeficiency.Semantic proximity Read ↗

Molecular and cellular pathogenesis of X-linked lymphoproliferative disease.Semantic proximity Read ↗

X-Linked Lymphoproliferative Disease Type 1: A Clinical and Molecular Perspective.Semantic proximity Read ↗

X-linked lymphoproliferative disease is caused by deficiency of a novel SH2 domain-containing signal transduction adaptor protein.Semantic proximity Read ↗

The impact of telomere erosion on memory CD8+ T cells in patients with X-linked lymphoproliferative syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.