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Article

X-Linked Lymphoproliferative Disease Type 1: A Clinical and Molecular Perspective.

Frontiers in immunology - 1 Jan 2018

Panchal Neelam, Booth Claire, Cannons Jennifer L, Schwartzberg Pamela L

Abstract excerpt

X-linked lymphoproliferative disease (XLP) was first described in the 1970s as a fatal lymphoproliferative syndrome associated with infection with Epstein-Barr virus (EBV). Features include hemophagocytic lymphohistiocytosis (HLH), lymphomas, and dysgammaglobulinemias. Molecular cloning of the causative gene, SH2D1A, has provided insight into the nature of disease, as well as helped characterize multiple features...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29670631
DOI: 10.3389/fimmu.2018.00666
PMCID: PMC5893764

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