A recessive mutant allele of the HNM1 gene of Saccharomyces cerevisiae is responsible for hyper-resistance to nitrogen mustard.

doi:10.1007/BF00318378

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Article

A recessive mutant allele of the HNM1 gene of Saccharomyces cerevisiae is responsible for hyper-resistance to nitrogen mustard.

Current genetics - 1 Oct 1990

Haase E, Brendel M

Abstract excerpt

A screening of haploid yeast strains for enhanced resistance to nitrogen mustard (HN2) yielded a recessive mutant allele, hnm1, that conferred hyper-resistance (HYR) to HN2. Diploids, homo- or heterozygous for the HNM1 locus, exhibit normal wild-type like resistance while homozygosity for hnm1 le...

Topics

Alleles
Drug Resistance, Microbial
Genes, Fungal
Genes, Recessive
Genetic Complementation Test
Haploidy
Mechlorethamine
Mutation
Phenotype
Saccharomyces cerevisiae

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