A novel yeast gene, RHK1, is involved in the synthesis of the cell wall receptor for the HM-1 killer toxin that inhibits beta-1,3-glucan synthesis.

doi:10.1007/s004380050401

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Article

A novel yeast gene, RHK1, is involved in the synthesis of the cell wall receptor for the HM-1 killer toxin that inhibits beta-1,3-glucan synthesis.

Molecular & general genetics : MGG - 26 Mar 1997

Kimura T, Kitamoto N, Kito Y, Iimura Y, Shirai T, Komiyama T, Furuichi Y, Sakka K, Ohmiya K

Abstract excerpt

The HM-1 killer toxin from Hansenula mrakii is known to inhibit cell wall beta-1,3-glucan synthase of Saccharomyces cerevisiae and other sensitive strains of yeast. A number of mutants of Saccharomyces cerevisiae that show resistance to this toxin were isolated in order to clarify the killing mec...

Topics

Amino Acid Sequence
Animals
Cell Wall
Drug Resistance, Microbial
Fungal Proteins
Genes, Fungal
Genetic Complementation Test
Glucans
Humans
Killer Factors, Yeast
Mannosyltransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Proteins

Microscopy, Electron, Scanning

Molecular Sequence Data

Mutation

Mycotoxins

Pichia

Receptors, Cell Surface

Source

Open in PubMed

Identifiers

PMID: 9108275
DOI: 10.1007/s004380050401

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9108275-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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A novel yeast gene, RHK1, is involved in the synthesis of the cell wall receptor for the HM-1 killer toxin that inhibits beta-1,3-glucan synthesis.PMID 9108275Read ↗

HKR1 encodes a cell surface protein that regulates both cell wall beta-glucan synthesis and budding pattern in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

N-glycosylation is involved in the sensitivity of Saccharomyces cerevisiae to HM-1 killer toxin secreted from Hansenula mrakii IFO 0895.Semantic proximity Read ↗

Involvement of cell wall beta-glucan in the action of HM-1 killer toxin.Semantic proximity Read ↗

A Saccharomyces cerevisiae genome-wide mutant screen for altered sensitivity to K1 killer toxin.Semantic proximity Read ↗

Killer-toxin-resistant kre12 mutants of Saccharomyces cerevisiae: genetic and biochemical evidence for a secondary K1 membrane receptor.Semantic proximity Read ↗

Expression of K1 Toxin Derivatives in Saccharomyces cerevisiae Mimics Treatment with Exogenous Toxin and Provides a Useful Tool for Elucidating K1 Mechanisms of Action and Immunity.Semantic proximity Read ↗

The KNH1 gene of Saccharomyces cerevisiae is a functional homolog of KRE9.Semantic proximity Read ↗

Isolation and characterization of Saccharomyces cerevisiae mutants with a different degree of resistance to killer toxins K1 and K2.Semantic proximity Read ↗

A mutational analysis of killer toxin resistance in Saccharomyces cerevisiae identifies new genes involved in cell wall (1-->6)-beta-glucan synthesis.Semantic proximity Read ↗

Genetic and molecular approaches to synthesis and action of the yeast killer toxin.Semantic proximity Read ↗

P-type ATPase spf1 mutants show a novel resistance mechanism for the killer toxin SMKT.Semantic proximity Read ↗

Isolation of Candida glabrata homologs of the Saccharomyces cerevisiae KRE9 and KNH1 genes and their involvement in cell wall beta-1,6-glucan synthesis.Semantic proximity Read ↗

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