Article
Hyper-resistance to nitrogen mustard in Saccharomyces cerevisiae is caused by defective choline transport.
Current genetics - 1 Jun 1991
Li Z Y, Haase E, Brendel M
Abstract excerpt
The recessive hnm1 mutant allele is responsible for hyper-resistance to nitrogen mustard in Saccharomyces cerevisiae. Transformation with a single-copy HNM1 wild-type allele of such hyper-resistant mutants will restore wild-type sensitivity to nitrogen mustard. By contrast the presence of multi-copy vectors containing HNM1, in either a hyper-resistant hnm1 mutant or an HNM1 wild-type, will lead to a novel,...
Topics
- Alleles
- Biological Transport
- Choline
- Cloning, Molecular
- DNA Damage
- Drug Resistance, Microbial
- Genes, Fungal
- Mechlorethamine
- Phenotype
- Saccharomyces cerevisiae