Article
Unprecedented intraspecific diversity of the MHC class I region of a teleost medaka, Oryzias latipes.
Immunogenetics - 1 Jul 2005
Tsukamoto Kentaro, Hayashi Shinpei, Matsuo Megumi Y, Nonaka Mayumi I, Kondo Mariko, Shima Akihiro, Asakawa Shiuchi, Shimizu Nobuyoshi, Nonaka Masaru
Abstract excerpt
The major histocompatibility complex (MHC) is present at a single chromosomal locus of all jawed vertebrate analyzed so far, from sharks to mammals, except for teleosts whose orthologs of the mammalian MHC-encoded genes are dispersed at several chromosomal loci. Even in teleosts, several class IA genes and those genes directly involved in class I antigen presentation preserve their linkage, defining the teleost...
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