Article

Automated compound testing in zebrafish xenografts identifies combined MCL-1 and BCL-X <sub>L</sub> inhibition to be effective against Ewing sarcoma

2021-06-17

Abstract excerpt

Ewing sarcoma is a pediatric bone and soft tissue cancer for which new therapies to improve disease outcome and to reduce adverse effects of current standard treatments are urgently needed. To identify new and effective drugs, phenotypic drug screening has proven to be a powerful method and a cancer model ideally suited for this approach is the larval zebrafish xenograft system. Complementing mouse xenografts, zeb...

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Literature Corpus work: 1e7939b6-6016-5db9-a6cb-6d2fdc55496f
DOI: 10.1101/2021.06.17.448794

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Automated compound testing in zebrafish xenografts identifies combined MCL-1 and BCL-X <sub>L</sub> inhibition to be effective against Ewing sarcomaDOI 10.1101/2021.06.17.448794Read

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