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Article

Somatic Genomic Alterations in Haematological Tumours Can Interfere With Accurate HLA and Chimerism Diagnostics.

HLA - 1 Mar 2025

Olieslagers Timo I, Groeneweg Mathijs, van Gorkom Gwendolyn N Y, Beckers Erik A M, Wieten Lotte, Voorter Christina E M

Abstract excerpt

Tumour cells, which are often found in the peripheral blood of patients with acute leukaemia, may harbour multiple somatic alterations throughout the genome, including changes in the HLA region and short tandem repeat (STR) regions. We investigated whether such somatic alterations interfere with HLA and chimerism diagnostics conducted in preparation for an allogeneic haematopoietic stem cell transplantation...

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Topics

Humans
Hematologic Neoplasms
Hematopoietic Stem Cell Transplantation
Male
Female
HLA Antigens

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Chimerism

Microsatellite Repeats

Middle Aged

Adult

Histocompatibility Testing

Alleles

Mutation

Haplotypes

Transplantation, Homologous

Source

Open in PubMed Open full text

Identifiers

PMID: 40071308
DOI: 10.1111/tan.70093
PMCID: PMC11897862

Provenance

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