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Article

Crystal structure of a supercharged variant of the human enteropeptidase light chain.

Proteins - 1 Jul 2012

Simeonov Peter, Zahn Michael, Sträter Norbert, Zuchner Thole

Abstract excerpt

The highly specific serine protease human enteropeptidase light chain cleaves the Asp4Lys recognition sequence and represents an interesting enzyme for biotechnological applications. The human enzyme shows 10 times faster kinetics compared to other animal sources but low solubility under low salt conditions, which hampers protein production and crystallization. Therefore, a supercharged variant...

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PMID: 22488687
DOI: 10.1002/prot.24084

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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