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Article

The functional variant V433M of the CYP4F2 and the metabolic syndrome in Swedes.

Prostaglandins & other lipid mediators - 1 May 2012

Fava Cristiano, Montagnana Martina, Danese Elisa, Sjögren Marketa, Almgren Peter, Guidi Gian Cesare, Hedblad Bo, Engström Gunnar, Minuz Pietro, Melander Olle

Abstract excerpt

BACKGROUND AND AIM: The genetic basis of Metabolic syndrome (MetS) is largely unknown but a link with salt sensitivity is recognized. The cytochrome P450 isoform 4F2 (CYP4F2) is involved in renal production of 20-hydroxyeicosatethraenoic acid (20-HETE), a natriuretic substance associated with salt sensitivity. The same enzyme is implicated in ω-hydroxylation of very long and medium chain fatty acids in the liver...

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Identifiers

PMID: 22484021
DOI: 10.1016/j.prostaglandins.2012.03.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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