Article
A variant upstream of the CDH13 adiponectin receptor gene and metabolic syndrome in Swedes.
The American journal of cardiology - 15 Nov 2011
Fava Cristiano, Danese Elisa, Montagnana Martina, Sjögren Marketa, Almgren Peter, Guidi Gian Cesare, Hedblad Bo, Engström Gunnar, Lechi Alessandro, Minuz Pietro, Melander Olle
Abstract excerpt
Metabolic syndrome (MetS) constitutes a worldwide epidemic burst accounting for billions of cardiovascular disease events and deaths. The genetic basis of MetS is largely unknown. The rs11646213 T → A polymorphism maps at 16q23.3 upstream of the CDH13 gene codifying for cadherin-13 (also known as T-cadherin or H-cadherin), which is considered a vascular adiponectin receptor. This and other single-nucleotide...
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