Article
Manic depressive illness not linked to factor IX region in an independent series of pedigrees.
Genomics - 1 Dec 1990
Gejman P V, Detera-Wadleigh S, Martinez M M, Berrettini W H, Goldin L R, Gelernter J, Hsieh W T, Gershon E S
Abstract excerpt
We studied seven informative kindreds segregating for manic depressive illness (MDI), consistent with X-chromosome transmission of the trait (families do not show affective disease in both a father and a son), using markers mapped to the region of Xq27-Xq28. The lod scores were consistently below -2 in the region extending from about 10 cM centromeric from the Factor IX locus (F9) to the colorblindness region....
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