Manic depressive illness not linked to factor IX region in an independent series of pedigrees.

doi:10.1016/0888-7543(90)90251-o

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Article

Manic depressive illness not linked to factor IX region in an independent series of pedigrees.

Genomics - 1 Dec 1990

Gejman P V, Detera-Wadleigh S, Martinez M M, Berrettini W H, Goldin L R, Gelernter J, Hsieh W T, Gershon E S

Abstract excerpt

We studied seven informative kindreds segregating for manic depressive illness (MDI), consistent with X-chromosome transmission of the trait (families do not show affective disease in both a father and a son), using markers mapped to the region of Xq27-Xq28. The lod scores were consistently below...

Topics

Bipolar Disorder
Factor IX
Female
Genetic Linkage
Humans
Lod Score
Male
Pedigree
Phenotype
Polymorphism, Restriction Fragment Length
X Chromosome

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