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Article

The tyrosine kinase c-Src directly mediates growth factor-induced Notch-1 and Furin interaction and Notch-1 activation in pancreatic cancer cells.

PloS one - 1 Jan 2012

Ma Yong-Chao, Shi Chong, Zhang Yao-Nan, Wang Lan-Ge, Liu Hao, Jia Hong-Ti, Zhang Yu-Xiang, Sarkar Fazlul H, Wang Ze-Sheng

Abstract excerpt

The proteolytic activity of Furin responsible for processing full length Notch-1 (p300) plays a critical role in Notch signaling. The amplitude and duration of Notch activity can be regulated at various points in the pathway, but there has been no report regarding regulation of the Notch-1-Furin interaction, despite its importance. In the present study, we found that the Notch-1-Furin interaction is regulated by...

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Identifiers

PMID: 22479394
DOI: 10.1371/journal.pone.0033414
PMCID: PMC3316571

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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