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Article

Polymorphisms in genes encoding interleukin-10 and drug metabolizing enzymes GSTP1, GSTT1, GSTA1 and UGT1A1 influence risk and outcome in Hodgkin lymphoma.

Leukemia & lymphoma - 1 Oct 2012

Yri Olav E, Ekstrøm Per O, Hilden Vera, Gaudernack Gustav, Liestøl Knut, Smeland Erlend B, Holte Harald

Abstract excerpt

We genotyped 224 patients with Hodgkin lymphoma (HL) and 1056 healthy controls and related the risk for HL and outcome of chemotherapy treatment to polymorphisms in genes encoding interleukins and metabolizing enzymes by capillary electrophoresis. Patients with the UGT1A1 TA tandem repeat TA6/6 genotype had a poorer overall survival (OS) (relative risk [RR] 3.63, p = 0.004), and patients above 40 years with the...

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Source

Identifiers

PMID: 22475179
DOI: 10.3109/10428194.2012.682307

Genes

GSTA1
GSTP1
GSTT1
EFS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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