Oligonucleotide ligation assay (OLA) for the diagnosis of familial hypercholesterolemia.

doi:10.1038/nbt1096-1279

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Article

Oligonucleotide ligation assay (OLA) for the diagnosis of familial hypercholesterolemia.

Nature biotechnology - 1 Oct 1996

Baron H, Fung S, Aydin A, Bähring S, Luft F C, Schuster H

Abstract excerpt

More than half of all deaths in Western society are related to arteriosclerotic cardiovascular diseases. Inherited disturbances in the low-density-lipoprotein (LDL) receptor and similar lipid-related defects account for the majority of these deaths. Testing procedures thus far rely on total chole...

Topics

Apolipoproteins B
Base Sequence
Biotechnology
DNA Mutational Analysis
DNA Primers
Genetic Techniques
Genetic Testing
Genotype
Humans
Hyperlipoproteinemia Type II
Mutation
Oligonucleotide Probes
Polymerase Chain Reaction
Receptors, LDL

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