Article
Rapid prenatal diagnosis of sickle cell diseases using oligonucleotide ligation assay coupled with laser-induced capillary fluorescence detection.
Prenatal diagnosis - 1 Aug 2002
Day Nancy S, Tadin Marija, Christiano Angela M, Lanzano Patricia, Piomelli Sergio, Brown Stephen
Abstract excerpt
Prenatal diagnosis of sickle cell diseases has been available for several years, and our laboratory has performed over 1000 prenatal diagnoses. However, currently available techniques are labor-intensive and time-consuming, and thus the diagnosis is delayed, making the mother's decision difficult. We describe a rapid, high-throughput technique based on the ligation assay coupled with automated capillary...
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