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Article

Alternative methods for H1 simulations in genome-wide association studies.

Human heredity - 1 Jan 2012

Perduca V, Sinoquet C, Mourad R, Nuel G

Abstract excerpt

OBJECTIVE: Assessing the statistical power to detect susceptibility variants plays a critical role in genome-wide association (GWA) studies both from the prospective and retrospective point of view. Power is empirically estimated by simulating phenotypes under a disease model H1. For this purpose, the gold standard consists in simulating genotypes given the phenotypes (e.g. Hapgen). We introduce here an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 22472690
DOI: 10.1159/000336194

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