Article
LCP1-mediated cytoskeleton alterations involve in arsenite-triggered malignant phenotype of human immortalized prostate stromal cells.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 1 Apr 2024
Yang Yiping, Zhou Menghan, Huang Yurun, Ye Xiaotong, Mo Yingxi, Huang Yi, Wang Shan
Abstract excerpt
The connection between continuous arsenic exposure and prostate cancer is already established. However, the exact mechanisms of arsenic tumorigenesis are far from clear. Here, we employed human prostate stromal immortalized cells (WPMY-1) continuous exposure to 1 and 2 μM arsenite for 29 weeks to identify the malignant phenotype and explore the underlying molecular mechanism. As expected, continuous low-dose...
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