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Article

Stratification of Wilms tumor by genetic and epigenetic analysis.

Oncotarget - 1 Mar 2012

Scott Richard H, Murray Anne, Baskcomb Linda, Turnbull Clare, Loveday Chey, Al-Saadi Reem, Williams Richard, Breatnach Fin, Gerrard Mary, Hale Juliet, Kohler Janice, Lapunzina Pablo, Levitt Gill A, Picton Sue, Pizer Barry, Ronghe Milind D, Traunecker Heidi, Williams Denise, Kelsey Anna, Vujanic Gordan M, Sebire Neil J, Grundy Paul, Stiller Charles A, Pritchard-Jones Kathy, Douglas Jenny, Rahman Nazneen

Abstract excerpt

Somatic defects at five loci, WT1, CTNNB1, WTX, TP53 and the imprinted 11p15 region, are implicated in Wilms tumor, the commonest childhood kidney cancer. In this study we analysed all five loci in 120 Wilms tumors. We identified epigenetic 11p15 abnormalities in 69% of tumors, 37% were H19 epimutations and 32% were paternal uniparental disomy (pUPD). We identified mutations of WTX in 32%, CTNNB1 in 15%, WT1 in...

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Identifiers

PMID: 22470196
DOI: 10.18632/oncotarget.468
PMCID: PMC3359888

Genes

CTNNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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