Article
Association of the DNA repair SMUG1 rs3087404 polymorphism and its interaction with high sensitivity C-reactive protein for age-related macular degeneration in Iranian patients.
Ophthalmic genetics - 1 Jan 2000
Bonyadi Mortaza, Mehdizadeh Faride, Jabbarpoor Bonyadi Mohammad Hossein, Soheilian Masoud, Javadzadeh Alireza, Yaseri Mehdi
Abstract excerpt
BACKGROUND: Age-related macular degeneration (AMD) is a complex disease and recently the role of DNA repairing genes in its susceptibility has been studied. It has been hypothesized that polymorphism in DNA repair system genes reduce the capacity to repair DNA damages which may lead to a greater susceptibility to AMD. C-reactive protein (CRP) production is shown to enhance inflammatory processes by increasing...
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