Article
Associations between ABCB1, CYP2A6, CYP2B6, CYP2D6, and CYP3A5 alleles in relation to efavirenz and nevirapine pharmacokinetics in HIV-infected individuals.
Therapeutic drug monitoring - 1 Apr 2012
Heil Sandra G, van der Ende Marchina E, Schenk Paul W, van der Heiden Ilse, Lindemans Jan, Burger David, van Schaik Ron H N
Abstract excerpt
BACKGROUND: Human immunodeficiency virus (HIV)-infected individuals show large interindividual variation in response to antiretroviral therapy. Efavirenz (EFV) and nevirapine (NVP) are nonnucleoside reverse transcriptase inhibitors, which are prescribed in combination with other antiretroviral therapy in so-called highly active antiretroviral therapy. Recent studies provide evidence for the role of cytochrome...
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