Article
Using graded response model for the prediction of prostate cancer risk.
Human genetics - 1 Aug 2012
Chen Shyh-Huei, Ip Edward H, Xu Jianfeng, Sun Jielin, Hsu Fang-Chi
Abstract excerpt
Disease risk-associated single nucleotide polymorphisms (SNPs) identified from genome-wide association studies (GWAS) have the potential to be used for disease risk prediction. An important feature of these risk-associated SNPs is their weak individual effect but stronger cumulative effect on disease risk. To date, a stable summary estimate of the joint effect of genetic variants on disease risk prediction is not...
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