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Systematic evaluation of narrow-sense validity of polygenic risk score for prostate cancer in a Chinese prostate biopsy cohort.

Clinical genetics - 1 Jun 2023

Wu Yishuo, Ruan Xiaohao, Gao Peng, Da Huang, Fang Zujun, Xu Danfeng, Jiang Haowen, Ding Qiang, Lin Xiaoling, Lu Daru, Na Rong

Abstract excerpt

The aim of this study was to assess the narrow-sense validity of polygenic risk score (PRS) for prostate cancer (PCa) in a Chinese prostate biopsy cohort. We performed an observational prospective study with 2640 men who underwent prostate biopsy. Germline DNA samples were genotyped and PRS was calculated for each subject using 17 PCa risk-associated genetic variants. Additional GWAS data of the ChinaPCa dataset...

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PMID: 36840471
DOI: 10.1111/cge.14315

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