14-3-3 binds to and mediates phosphorylation of microtubule-associated tau protein by Ser9-phosphorylated glycogen synthase kinase 3beta in the brain.

doi:10.1074/jbc.M308298200

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Article

14-3-3 binds to and mediates phosphorylation of microtubule-associated tau protein by Ser9-phosphorylated glycogen synthase kinase 3beta in the brain.

The Journal of biological chemistry - 18 Jun 2004

Yuan Zongfei, Agarwal-Mawal Alka, Paudel Hemant K

Abstract excerpt

In mammalian brain, tau, glycogen synthase kinase 3beta (GSK3beta), and 14-3-3, a phosphoserine-binding protein, are parts of a multiprotein tau phosphorylation complex. Within the complex, 14-3-3 simultaneously binds to tau and GSK3beta (Agarwal-Mawal, A., Qureshi, H. Y., Cafferty, P. W., Yuan, Z., Han, D., Lin, R., and Paudel, H. K. (2003) J. Biol. Chem. 278, 12722-12728). The molecular mechanism by which...

Topics

14-3-3 Proteins
Alanine
Animals
Brain
Cell Line
Cells, Cultured
Cloning, Molecular
DNA, Complementary
Glutathione
Glutathione Transferase
Glycogen Synthase Kinase 3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Glycogen Synthase Kinase 3 beta

Humans

Microtubules

Mutation

Phosphorylation

Plasmids

Precipitin Tests

Source

Open in PubMed

Identifiers

PMID: 15073173
DOI: 10.1074/jbc.M308298200

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