The Psen1‐L166P ‐knock‐in mutation leads to amyloid deposition in human wild‐type amyloid precursor protein YAC transgenic mice

Abstract excerpt

ABSTRACT Genetically engineered mice have been generated to model cerebral β‐amyloidosis, one of the hallmarks of Alzheimer disease (AD) pathology, based on the overexpression of a mutated cDNA of the amyloid‐β precursor protein ( A β PP ) or by knock‐in of the murine A β pp gene alone or with presenilin1 mutations. Here we describe the generation and initial characterization of a new mouse line based on the...

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