Article
Polarized expression of the membrane ASP protein derived from HIV-1 antisense transcription in T cells.
Retrovirology - 19 Sept 2011
Clerc Isabelle, Laverdure Sylvain, Torresilla Cynthia, Landry Sébastien, Borel Sophie, Vargas Amandine, Arpin-André Charlotte, Gay Bernard, Briant Laurence, Gross Antoine, Barbeau Benoît, Mesnard Jean-Michel
Abstract excerpt
BACKGROUND: Retroviral gene expression generally depends on a full-length transcript that initiates in the 5' LTR, which is either left unspliced or alternatively spliced. We and others have demonstrated the existence of antisense transcription initiating in the 3' LTR in human lymphotropic retroviruses, including HTLV-1, HTLV-2, and HIV-1. Such transcripts have been postulated to encode antisense proteins...
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