Article
Polymorphisms of MTHFR and MTR genes are not related to susceptibility to childhood ALL in North India.
Experimental oncology - 1 Jan 2012
Nikbakht M, MalekZadeh K, Kumar Jha A, Askari M, Marwaha R K, Kaul D, Kaur J
Abstract excerpt
BACKGROUND: Acute lymphoblastic leukemia (ALL) is the most worldwide common type of childhood cancer. Methylenetetrahydrofolate reductase (MTHFR) and 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR) participate in folate pathways and are known as critical factors for DNA integrity as well as DNA hypomethylation. The aim of this work is to investigate frequency of MTHFR (677C→T and 1298A→C) and MTR...
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