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Article

Genome-wide DNA methylation profiling identifies two novel genes in cervical neoplasia.

International journal of cancer - 1 Sept 2020

El-Zein Mariam, Cheishvili David, Gotlieb Walter, Gilbert Lucy, Hemmings Robert, Behr Marcel A, Szyf Moshe, Franco Eduardo L

Abstract excerpt

DNA methylation analysis may improve risk stratification in cervical screening. We used a pan-epigenomic approach to identify new methylation markers along the continuum of cervical intraepithelial neoplasia (CIN) to cervical cancer. Physician-collected samples (54 normal, 50 CIN1, 40 CIN2 and 42 CIN3) were randomly selected from women at a single-center colposcopy clinic. Extracted DNA was subjected to Illumina...

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PMID: 31983058
DOI: 10.1002/ijc.32880

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