Article
Regulation of the gene encoding human thrombin-activatable fibrinolysis inhibitor by estrogen and progesterone.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Jun 2013
Garand Mathieu, Lin Joellen H H, Zagorac Branislava, Koschinsky Marlys L, Boffa Michael B
Abstract excerpt
Thrombin-activatable fibrinolysis inhibitor (TAFI) is a pro-carboxypeptidase B-like pro-enzyme that upon activation attenuates fibrinolysis and inflammatory processes. There is a large inter-individual variability in plasma TAFI levels within the population which is primarily due to epigenetic factors. Novel associations between plasma TAFI levels and sex steroids have triggered interest in determining the role...
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