Article
Evidence for elevated mutation rates in low-quality genotypes.
Proceedings of the National Academy of Sciences of the United States of America - 17 Apr 2012
Sharp Nathaniel P, Agrawal Aneil F
Abstract excerpt
The deleterious mutation rate plays a key role in a number of important topics in biology, from mating system evolution to human health. Despite this broad significance, the nature and causes of variation in mutation rate are poorly understood, especially in multicellular organisms. We test whether genetic quality, the presence or absence of deleterious alleles, affects the mutation rate in Drosophila...
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